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Aldara Cream Side Effects – Proper Use To Avoid Problems

Although aldara cream may be an answer to the question Can Genital Warts Be Cured, as with any medication it needs to be used properly. Using aldara cream as directed is going to minimize many potential aldara cream side effects.

When aldara cream is prescribed in most cases the cream should come with instructions from your doctor for the most appropriate use and dosages. These instructions will include when to use it, where to apply it, how much to apply and when to not use the cream.

In order to avoid aldara cream side effects it should be applied as in the following steps:

Aldara cream should not be applied anywhere except to the treatment area. Can you buy imiquimod 5% cream over the counter It must not be applied to open wounds or to scraped, blistered, infected, or sunburned skin.

It should not be applied internally.

You should apply Aldara just before bedtime, unless your doctor has advised otherwise.

Wash your hands before and after using Aldara.

Wash the affected area before using Aldara. Apply the cream to dry skin.

It is important to not leave the medicine on the skin for longer than your doctor tells you. When it is time to remove it, you can use mild soap and water as directed by your doctor.

Do not skip any doses. Follow your doctors’ instructions if you do miss a dose.

Following those basic guidelines along with the exact directions provided by a doctor or health care professional should help to minimize any aldara cream side effects due to misuse of the product.

Will I Get Any Side Effects From ALDARA Cream?

There are some side effects associated with ALDARA cream. Side effects are most often at the wart area and are usually mild to moderate.

Most common side effects are redness, peeling, and swelling in the area where ALDARA cream is applied. Some patients have also experienced burning, itching, and pain where ALDARA cream was applied.

These may be caused by the response of your body’s immune system to the drug. However, if you experience a severe skin reaction, contact your health care provider.

Pharmacodynamics

The mechanism of action of Aldara Cream in treating actinic keratosis (AK) lesions is unknown. In a study of 18 patients with AK comparing Aldara Cream to vehicle, increases from baseline in week 2 biomarker levels were reported for CD3, CD4, CD8, CD11c, and CD68 for Aldara Cream treated patients; however, the clinical relevance of these findings is unknown.

Superficial Basal Cell Carcinoma

The mechanism of action of Aldara Cream in treating superficial basal cell carcinoma (sBCC) lesions is unknown. An open label study in six subjects with sBCC suggests that treatment with Aldara Cream may increase the infiltration of lymphocytes, dendritic cells, and macrophages into the tumor lesion; however, the clinical significance of these findings is unknown.

External Genital Warts

Imiquimod has no direct antiviral activity in cell culture. A study in 22 patients with genital/perianal warts comparing Aldara Cream and vehicle shows that Aldara Cream induces mRNA encoding cytokines including interferon-(alpha) at the treatment site. In addition HPVL1 mRNA and HPV DNA are significantly decreased following treatment. However, the clinical relevance of these findings is unknown.

Abstract

Background: Increasing evidence suggests imiquimod may be a safe therapeutic option for the treatment of actinic keratosis (AK). http://www.drugs.com/dosage/imiquimod-topical.html The diagnosis and assessment of most AK lesions is made clinically, without histologic confirmation.

Objective: A phase III, randomized, double-blind, parallel group, vehicle-controlled study evaluated the efficacy of imiquimod 5% cream compared with vehicle in the treatment of AK lesions on the face and balding scalp including pretreatment and posttreatment biopsy specimens.

Methods: A total of 286 patients at 18 centers in 6 European countries with histologically confirmed AK were randomized to either imiquimod 5% cream or vehicle cream. Study cream was applied once per day, 3 days per week, for 16 weeks. Clearance of AK lesions was clinically and histologically assessed at an 8-week posttreatment visit.

Results: The complete clearance rate for the imiquimod group was 57.1% versus 2.2% for the vehicle group (P or =75% reduction in baseline lesions) for the imiquimod group was 72.1% versus 4.3% for the vehicle group (P Conclusion: Imiquimod 5% cream used 3 times per week for 16 weeks is an effective treatment for AK. Clinical clearance was established by both clinical observation and histologic analysis.